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陈华民

      

 

陈华民,男,1973年4月出生,河南浚县人。现任中国农业 科学院副研究员、硕士生导师。

1996年获沈阳农业大学农产品贮藏与加工专业学士学位,1999年获沈阳农业大学植物病理学硕士学位,2008年获上海交通大学生物化学与分子生物学博士学位。2004-2008年于北京生命研究所联合培养博士,2013-2014年于加州大学戴维斯分校访学一年。2008年-至今,奔驰宝马游戏平台从事科研工作,兼任北京植物病理学会理事。

陈华民长期从事植物病理学领域相关研究,早期揭示了乙烯信号途径关键转录因子EIN3EIL1通过水杨酸信号途径调控植物先天免疫的作用机制;建立了蛋白-蛋白互作的荧光素酶片段互补图像技术。当前以水稻-水稻白叶枯病菌为研究模式,致力于水稻抗病信号传导机制、白叶枯病菌致病机理的研究,针对生产上高氮肥加重植物病害为害的实际问题,致力于植物抗病性与氮素吸收利用间关联机制的解析。研究成果曾分别在Plant Cell,Sci Adv,Plant Physiol,New Phytol,Mol Plant Pathol,MPMI,Rice,Plant Cell Physiol,Appl Environ Microbiol等杂志上发表。先后主持国家自然科学基金面上项目2项、863计划子课题1项、农业行业科研专项子课题1项,参加十三五重点研发专项、国家转基因重大专项、中国农科院创新工程等多项。

发表论文:

1.Yu, C.; Nguyen, D. P.; Ren, Z.; Liu, J.; Yang, F.; Tian, F.; Fan, S.; Chen, H.*, The RpoN2-PilRX regulatory system governs type IV pilus gene transcription and is required for bacterial motility and virulence in Xanthomonas oryzae pv. oryzae. Mol Plant Pathol 2020, 21 (5): 652-666.

2.Li, H.; Xue, D.; Tian, F.*; Yuan, X.; Yang, F.; Chen, H.; Hutchins, W.; Yang, C. H.; He, C.*, Xanthomonas oryzae pv. oryzae response regulator TriP regulates virulence and exopolysaccharide production via interacting with c-di-GMP phosphodiesterase PdeR. Mol Plant Microbe Interact 2019, 32(6): 729-739.

3.Yu, C.; Chen, Y.; Cao, Y.; Chen, H.*; Wang, J.; Bi, Y. M.; Tian, F.; Yang, F.; Rothstein, S. J.; Zhou, X.; He, C., Overexpression of miR169o, an Overlapping MicroRNA in Response to Both Nitrogen Limitation and Bacterial Infection, Promotes Nitrogen Use Efficiency and Susceptibility to Bacterial Blight in Rice. Plant Cell Physiol 2018, 59 (6): 1234-1247.

4.Yu, C.; Chen, H.; Tian, F.; Yang, F.; Yuan, X.; Yang, C. H.; He, C.*, A ten gene-containing genomic island determines flagellin glycosylation: implication for its regulatory role in motility and virulence of Xanthomonas oryzae pv. oryzae. Mol Plant Pathol 2018, 19 (3): 579-592.

5.Xue, D.; Tian, F.*; Yang, F.; Chen, H.; Yuan, X.; Yang, C. H.; Chen, Y.; Wang, Q.; He, C., Phosphodiesterase EdpX1 Promotes Xanthomonas oryzae pv. oryzae Virulence, Exopolysaccharide Production, and Biofilm Formation. Appl Environ Microbiol 2018, 84 (22): e01717-18.

6.Qin, J.; Zhou, X.; Sun, L.; Wang, K.; Yang, F.; Liao, H.; Rong, W.; Yin, J.; Chen, H.; Chen, X.*; Zhang, J.*, The Xanthomonas effector XopK harbours E3 ubiquitin-ligase activity that is required for virulence. New Phytol 2018, 220 (1): 219-231.

7.Yu, C.; Chen, H.; Tian, F.; Yang, F.; He, C., RpoN2- and FliA-regulated fliTX is indispensible for flagellar motility and virulence in Xanthomonas oryzae pv. oryzae. BMC Microbiol 2017, 17 (1): 171.

8.Fan, S.; Tian, F.*; Li, J.; Hutchins, W.; Chen, H.; Yang, F.; Yuan, X.; Cui, Z.; Yang, C. H.*; He, C., Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol Plant Pathol 2017, 18 (4): 555-568.

9.Yang, F.; Qian, S.; Tian, F.; Chen, H.; Hutchins, W.; Yang, C. H.; He, C.*, The GGDEF-domain protein GdpX1 attenuates motility, exopolysaccharide production and virulence in Xanthomonas oryzae pv. oryzae. J Appl Microbiol 2016, 120 (6): 1646-57.

10.Thomas, N. C.?; Schwessinger, B.?; Liu, F.; Chen, H.; Wei, T.; Nguyen, Y. P.; Shaker, I. W. F.; Ronald, P. C.*, XA21-specific induction of stress-related genes following Xanthomonas infection of detached rice leaves. PeerJ 2016, 4: e2446.

11.Yu, C.?; Wang, N.?; Wu, M.; Tian, F.; Chen, H.; Yang, F.; Yuan, X.; Yang, C. H.; He, C.*, OxyR-regulated catalase CatB promotes the virulence in rice via detoxifying hydrogen peroxide in Xanthomonas oryzae pv. oryzae. BMC Microbiol 2016, 16 (1): 269.

12.Yu, C.?; Chen, H. M.?; Tian, F.; Bi, Y. M.; Steven, R. J.; Jan, L. E.; He, C. Y.*, Identification of differentially-expressed genes of rice in overlapping responses to bacterial infection by Xanthomonas oryzae pv. oryzae and nitrogen deficiency. Journal of Integrative Agriculture 2015, 14 (5): 888-899.

13.Yang, F.; Tian, F.; Chen, H.; Hutchins, W.; Yang, C. H.; He, C.*, The Xanthomonas oryzae pv. oryzae PilZ Domain Proteins Function Differentially in Cyclic di-GMP Binding and Regulation of Virulence and Motility. Appl Environ Microbiol 2015, 81 (13): 4358-67.

14.Kang, S.; Yang, F.; Li, L.; Chen, H.; Chen, S.; Zhang, J.*, The Arabidopsis transcription factor BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1 is a direct substrate of MITOGEN-ACTIVATED PROTEIN KINASE6 and regulates immunity. Plant physiology 2015, 167 (3): 1076-86.

15.Li, H.; Yu, C.; Chen, H.; Tian, F.*; He, C., PXO_00987, a putative acetyltransferase, is required for flagellin glycosylation, and regulates flagellar motility, exopolysaccharide production, and biofilm formation in Xanthomonas oryzae pv. oryzae. Microb Pathog 2015, 85: 50-7.

16.Tian, F.; Yu, C.; Li, H.; Wu, X.; Li, B.; Chen, H.; Wu, M.; He, C.*, Alternative sigma factor RpoN2 is required for flagellar motility and full virulence of Xanthomonas oryzae pv. oryzae. Microbiol Res 2015, 170: 177-83.

17.Pruitt, R. N.?; Schwessinger, B.?*; Joe, A.; Thomas, N.; Liu, F.; Albert, M.; Robinson, M. R.; Chan, L. J. G.; Luu, D. D.; Chen, H.; Bahar, O.; Daudi, A.; De Vleesschauwer, D.; Caddell, D.; Zhang, W.; Zhao, X.; Li, X.; Heazlewood, J. L.; Ruan, D.; Majumder, D.; Chern, M.; Kalbacher, H.; Midha, S.; Patil, P. B.; Sonti, R. V.; Petzold, C. J.; Liu, C. C.; Brodbelt, J. S.; Felix, G.; Ronald, P. C.*, The rice immune receptor XA21 recognizes a tyrosine-sulfated protein from a Gram-negative bacterium. Science Advances 2015, 1 (6): e1500245.

18.Yu, C.?; Chen, H.?; Tian, F.; Leach, J. E.; He, C.*, Differentially-expressed genes in rice infected by Xanthomonas oryzae pv. oryzae relative to a flagellin-deficient mutant reveal potential functions of flagellin in host-pathogen interactions. Rice 2014, 7 (1): 20.

19.Yang, F.; Tian, F.; Li, X.; Fan, S.; Chen, H.; Wu, M.; Yang, C. H.; He, C.*, The degenerate EAL-GGDEF domain protein Filp functions as a cyclic di-GMP receptor and specifically interacts with the PilZ-domain protein PXO_02715 to regulate virulence in Xanthomonas oryzae pv. oryzae. Mol Plant Microbe Interact 2014, 27 (6): 578-89.

20.Li, X.*; Qiao, J.; Yang, L.; Li, X.; Qiao, S.; Pang, X.; Tian, F.; Chen, H.; He, C., Mutation of alkyl hydroperoxide reductase gene ahpC of Xanthomonas oryzae pv. oryzae affects hydrogen peroxide accumulation during the rice-pathogen interaction. Res Microbiol 2014, 165 (8): 605-11.

21.Yang, F.?; Tian, F.?; Sun, L.?; Chen, H.; Wu, M.; Yang, C. H.; He, C.*, A novel two-component system PdeK/PdeR regulates c-di-GMP turnover and virulence of Xanthomonas oryzae pv. oryzae. Mol Plant Microbe Interact 2012, 25 (10): 1361-9.

22.Yang, F.?; Tian, F.?; Sun, L.?; Chen, H.; Wu, M.; Yang, C. H.; He, C.*, A novel two-component system PdeK/PdeR regulates c-di-GMP turnover and virulence of Xanthomonas oryzae pv. oryzae. Mol Plant Microbe Interact 2012, 25 (10): 1361-9.

23.Chen, H.; Zou, Y.; Shang, Y.; Lin, H.; Wang, Y.; Cai, R.; Tang, X.; Zhou, J. M.*, Firefly luciferase complementation imaging assay for protein-protein interactions in plants. Plant Physiol 2008, 146 (2): 368-76.

24.胡积祥?曹雅倩?,朱秀梅,余超,田芳,杨凤环,陈华民*,何晨阳。基于瞬时表达系统的水稻miRNA靶基因快速验证系统的建立。生物技术通报2019, 35(10): 57-63.

25.陈禹彤陈华民*余超Amy Thein田芳何晨阳水稻miR169o及其靶基因OsNF-YAs对缺水胁迫的早期表达反应。生物技术通报 2015, 31(8): 76-81.

26.刘维振?陈华民?,于清,田芳,唐嘉义,何晨阳。鞭毛素蛋白FliCxcv对水稻免疫反应的诱导功能鉴定。植物病理学报 2015, 45(2): 151-157.

27.刘莹,陈华民,于清,田芳,鲁国东,何晨阳。鞭毛素蛋白诱导水稻免疫反应的活性测定。植物保护学报 2015, 42(1): 66-71.

28.伍甜,刘莹,余超,边强,田芳,黄琼,陈华民*,何晨阳。燕麦嗜酸菌鞭毛素的提纯及其活性检测。生物技术通报 2013, (7): 78-81